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KMID : 0388019940050020001
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Korean Journal Gynecologic Oncology and Colposcopy
1994 Volume.5 No. 2 p.1 ~ p.9
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The Assessment of Proliferating Cell Nuclear Antigen (PCNA) in Cervical Tumors
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Abstract
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Proliferating cell nuclear antigen (PCNS) is a nuclear protein that is synthesized in late G1 and S phases of cell cycle and is correlated with the cell proliferative state. The recent study demonstrated that PCNA functions in DNA replication.
The
present study evaluated proliferative indices (PI) for the assessment of tumor proliferation and for investigating prognostic significance in cervical tumors. Immunohistochemical PCNA staining was performed in formalin-fixed paraffinembedded
cervical
tissues via the avidinbiotin-complex immunoperoxidase method. Mean PI was 36.03±5.14% in normal controls, as compared to 66.19±11.36% in cervical intraepithelial neoplasia and 63.19±10.53% in invasive cervical cancer. Our results showed no
correlation between PI and histological type. Among invasive cervical cancer (24 cases), PI was 64.43±10.94% in squamous cell carcinoma and 59.00±4.10% in adenocarcinoma. There was no significant relationship between PI and clinical stage, and
between
PI and lesion size. This study suggests that PI may not serve as a new prognostic factor in cervical tumors.
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KEYWORD
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